Sr Scientist – Vector Engineering job opportunity at AstraZeneca.

Home Jobs In Belgium Tag: Job Sr Scientist – Vector Engineering position at AstraZeneca


DateMore Than 30 Days Ago bot
AstraZeneca Sr Scientist – Vector Engineering
Experience: 2-years
Pattern: full-time
Country:
apply Apply Now
Salary:
Status:

Job

Copy Link Report
degreePhD
loacation Belgium - Mont-Saint-Guibert, Belgium
loacation Belgium - Mont..........Belgium

Introduction to role  Are you ready to dive into the world of transformative therapies and make a significant impact? At EsoBiotec, now part of AstraZeneca, we are setting new benchmarks for biotechnological research. Our collaboration combines AstraZeneca’s global influence and scientific innovation with EsoBiotec’s unique culture of creativity and breakthroughs in cell-based therapies and immunology. Here, your scientific passion will drive real-world impact as you contribute to life-changing treatments.  We are looking for an inspiring discovery scientist to drive innovation and development of our pioneering lentiviral vector therapeutic platform. Join us in shaping the future of cell and gene therapy with your expertise in viral vector engineering, gene editing, CAR and TCR T cell engineering or myeloid immunobiology in cancer.  Responsibilities Design, build, and validate novel lentiviral vectors for in vivo cell therapy applications. Perform hands-on construct designs, viral genome optimization, viral envelope pseudotype engineering and vector assembly. Design, plan and execute in vitro and in vivo experiments to assess transduction efficiency, specificity, expression durability, and safety profile of novel in vivo LVVs. Develop and run assays for titer, potency, biodistribution, integration site analysis, and immunogenicity in collaboration with analytics partners. Apply literature mining, public datasets, and personal expertise to generate innovative, testable hypotheses and prioritize vector concepts. Implement rigorous experimental design, statistical analysis, and documentation to ensure reproducibility, traceability, and data integrity. Collaborate extensively with discovery teams across AZ including payload biology, bioinformatics, and nonclinical to align vector designs with product requirements. Contribute to platform development by creating screening workflows, model systems, and standardized protocols for vector performance. Present findings, risks, and recommendations in working groups and project meetings and drive decisions through clear data storytelling. Support IP generation by contributing to invention disclosures and sharing FTO considerations with the IP team. Essential Skills/Experience  PhD in molecular biology, virology, bioengineering, or related field with 2+ years of postdoctoral experience in academia or industry for Scientist and 4+ years in industry for Senior Scientist. Demonstrated expertise in viral vectors and virology with a strong track record in viral vector design, engineering, and characterization for gene therapy Proficiency in molecular biology techniques for vector construction, promoter and regulatory element engineering, and payload optimization. Experience in protein and antibody (scFV and VHH) engineering or envelope/pseudotype modification to tune tropism, entry, and transduction profiles. Hands-on familiarity with in vitro cell culture assays and in vivo models for vector evaluation including transduction assays, dose–response, durability studies, and safety readouts. Strong hands on competence with quantitative analytics such as flow cytometry and qPCR/ddPCR. Ability to design rigorous experiments, apply statistics, and interpret complex datasets to drive go/no-go decisions. Strong collaboration and communication skills to operate as a backbone member of cross-functional working groups and align discovery efforts with product goals. Evidence of innovation through publications, presentations, or open-source contributions and comfort leveraging literature and public data to ideate and de-risk. Organized, proactive, and product-focused mindset with the ability to manage multiple experiments, meet timelines, and maintain high-quality documentation. Commitment to being fully hands-on at the bench while mentoring peers and contributing to platform and program deliverables. Desirable Skills/Experience Strong preference for lentiviral vectors.  Practical understanding of safety risks and mitigations for LVV including insertional mutagenesis, off-target transduction, immunogenicity, and RCL testing.   AstraZeneca offers an environment where courage, curiosity, and collaboration thrive. With a bold vision to eliminate cancer as a cause of death, we are dedicated to transforming patient lives through innovative science. Our team is empowered to lead at every level, making smart decisions that drive our pipeline forward. Join us in pioneering collaborative research that unites academia and industry, expediting breakthroughs in some of the hardest-to-treat cancers.  So, what is next: Ready to make an impact? Apply now to join our mission-driven team ! To find out more: Company site: https://www.esobiotec.com/ Group site: https://www.astrazeneca.com/ Our social media, Follow us on LinkedIn: Esobiotec and AstraZeneca Inclusion & Diversity: https://careers.astrazeneca.com/inclusion-diversity Career site: https://careers.astrazeneca.com/ Date Posted 05-jan.-2026 Closing Date 30-jan.-2026 AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Other Ai Matches

Field Scientific Leader (Hematology) - Ankara Applicants are expected to have a solid experience in handling Job related tasks
Sales Representative Oncology (GYN GU) Applicants are expected to have a solid experience in handling Job related tasks
Local Study Manager / Clinical Project Lead (m/w/d) Onkologie Applicants are expected to have a solid experience in handling Job related tasks
Plant Maintenance Engineer - APICOM Applicants are expected to have a solid experience in handling Job related tasks
Key Account Manager GI/GU (Łódzkie, Opolskie, Śląskie) Applicants are expected to have a solid experience in handling Opolskie, Śląskie) related tasks
Oncology Associate Business Partner Applicants are expected to have a solid experience in handling Job related tasks
Senior Consultant - SAP Tax Consultant Applicants are expected to have a solid experience in handling Job related tasks
Japan Local Case Advisor, GBS Patient Safety Applicants are expected to have a solid experience in handling GBS Patient Safety related tasks
MR-呼吸生物制剂新产品-遵义 Applicants are expected to have a solid experience in handling Job related tasks
RSM-突破性多适应症生物制剂(南区)-广州 Applicants are expected to have a solid experience in handling Job related tasks
【AstraZeneca】【CET】CRM Platform Lead, Field capability & Launch excellence, Customer Experience & IT Applicants are expected to have a solid experience in handling Field capability & Launch excellence, Customer Experience & IT related tasks
Key Account Partner CVRM (Warszawa) - umowa na zastępstwo Applicants are expected to have a solid experience in handling Job related tasks
Biopharma Translational Medicine (Associate) Principal Scientist Applicants are expected to have a solid experience in handling Job related tasks
Global Head of Marketing – Clinical Development Health Tech Evinova Applicants are expected to have a solid experience in handling Job related tasks
Sr.Engineer,SHE Applicants are expected to have a solid experience in handling SHE related tasks
Senior Director, Global Quality and Operational Excellence, Site Management & Monitoring Applicants are expected to have a solid experience in handling Global Quality and Operational Excellence, Site Management & Monitoring related tasks
Marketing Director, LC Late Stage Applicants are expected to have a solid experience in handling LC Late Stage related tasks
Director Scientific Communications and Engagement Applicants are expected to have a solid experience in handling Job related tasks
Japan Local Case Advisor, GBS Patient Safety Applicants are expected to have a solid experience in handling GBS Patient Safety related tasks
RMM-Retail-南区 Applicants are expected to have a solid experience in handling Job related tasks
MR-RIN-徐州 Applicants are expected to have a solid experience in handling Job related tasks
Medical NPP (New Product Planning) Lead, Oncology/Hematology Applicants are expected to have a solid experience in handling Oncology/Hematology related tasks
Medical Science Liaison-gMG/NMOSD-Jinan Applicants are expected to have a solid experience in handling Job related tasks