Senior Scientist – Translational Genomics, Translational Medicine job opportunity at AstraZeneca.

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AstraZeneca Senior Scientist – Translational Genomics, Translational Medicine
Experience: 4-years
Pattern: full-time
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Translational Medicine

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loacation UK - Cambridge, United Kingdom
loacation UK - Cambridge....United Kingdom

Job Title: Senior Scientist   – Translational Genomics,   Translational Medicine Location: Cambridge, UK Introduction to the role: We are seeking a   Se nior Scientist   to join our   Translational G enomics   team   (Cambridge, U.K.)   on a fixed term basis (14 months) .   The successful candidate would be joining   a world class   centre   for   discovery   and development of innovative cancer medicines. Based at the heart of the Cambridge UK biomedical rese arch community you will play a key   role in the   delivery of data   utilizing   cutting edge   genomics techniques .   You will deliver high quality   biomarker   data from human clinical samples and   have the opportunity to   impact   an   exciting and   industry-leading portfolio of programs from   inception   through to   life cycle management.     About the role: The   Translational   Medicine   Genomics Lab   focuses on the   exploratory   analysis of clinical samples using the best available solutions to maximize value for oncology projects.   Our work includes the a nalysis of fixed and frozen tissues , liquid biopsy   material , and single cell and spatial genomics .   We provide support via a mix of in-house lab analyses, external providers, and collaborators. We generate data to help understand key cancer pathway alterations, guide drug combinations, provide disease linkage data to guide   indication   selection and targeted patient populations and   understand   the dynamics of response   and   resistance to therapies.     This role will   ha ve   a strong focus on hands-on laboratory work .   Y ou will   be responsible for   the   planning, design ,   and executi on of   high - quality experimental work   and   documenting , interpreting ,   and communicating results to   appropriate stakeholders   and partners. You will   be able to   work independently but   also as   a   key member of   our global   team   of genomics and   data science   experts.     Major Responsibilities and Accountabilities: Work wit h UK and Global genomics colleagues, Project Managers and   Translational   Medicine Leads (TMLs)   to understand the   genomic biomarker needs   of clinical studies   Plan , prioritise,   and execute work to deliver to   biomarker   plans   exploiting the most   appropriate technologies/assays   to deliver high quality data on time and to budget   Work with Translational, Clinical,   Biosamples   colleagues, and CRO partners, to access the right samples at the right time   Lead from the bench to ge nerate data in a modern genomics lab utilising Automation, DNA/RNA extraction,   library preparation,   NGS,   single cell,   and other platforms   Utilise a sample management system and other software and communication tools to track samples,   monitor   progress, and record data   Work   with team members and aligned production informatics and bioinformatics experts to support data analysis/QC,   interpretation   and communication back to   TML,   project team and other stakeholders   Contribute to maintenance and development of   our internal genomics capabilities   and development & implementation of new genomic/epigenomic assays or related technologies   Support colleagues to train in existing and new SOPs   As required - c onceptualize, develop, and execute evaluations of   methods,   platforms, and emerging technologies   which may   address   areas of unmet need for   programmes   Provide technical advice and genomic biomarker consultation to internal and external partner s   Record and communicate your data accurately,   clearly   and concisely   Maintain   appropriate documentation , be compliant with all internal and external policies and legal requirements   around use of clinical samples, consent, and privacy   Essential skills and experience: Advanced degree   in a relevant discipline   ( preferably   PhD   or equivalent )   and   a t least   4 years post-doctoral experience (or equivalent)   utilising advanced molecular biology techniques (academic or industrial setting) ; Recent/current experience   greatly   preferred   Experience of cancer genomics and analysis of   oncology   clinical specimens   Strong   current   laboratory and analytical skills   Evidence of effective problem-solving , method   development   and optimisation   Ability to understand and work to detailed SOPs   and to author   and troubleshoot   new SOPs   Excellent   oral and written communication skills, able to document work clearly, concisely, and understand and describe its importance to others   Good organisational and planning skills, ability to manage a portfolio of work , prioritize,   and deliver to agreed time and quality   Good interpersonal skills – able to work effectively with colleagues/collaborators from diverse backgrounds , levels of seniority,   and territories   Meticulous attention to detail, ability to document results to a high standard   Desirable skills and experience: Although training will be given where   required , e xperience in the following areas would be a distinct advantage:   Peer-reviewed publications in the   cancer biology/ cancer   genomics   field   Working in a commercial/industrial environment   W orking with   DNA/RNA from   human clinical materials such as formalin fixed paraffin-embedded tissues , frozen tissues, p lasma   ( circulating   cell- free DNA /cfDNA).   Hands- on laboratory experience preparing   DNA/RNA   libraries , targeted NGS,   and running NGS   platforms   W ork in single cell   genomics and/or spatial genomics ( e.g.   10x, Parse,   GeoMx   DSP )   Tissue culture, handling and purification of cells from clinical samples, e.g. PBMCs   Tissue dissociation for downstream single cell work   D eveloping and running assays   ( e.g.   mutation/copy number)   using digital PCR     C onducting   work   to Good Cl inical Practice (GCP )   within a   regulatory   /quality   framework (e .g. ISO   15189 - , CAP - , CLIA- accredited lab environment ).   A ssay   development for NGS platforms   W orking with laboratory automation   (particularly   Biomek   liquid handling systems ) , method development/optimisation   A nalysis and interpretation   of NGS data   from clinical specimens   Experience in the biotech/pharmaceutical industry and of the drug development process   When we put unexpected teams in the same room, we unleash ambitious thinking with the power to encourage life‑changing medicines. In‑person working helps us connect, work at pace and challenge perceptions. We work, on average, a minimum of three days per week from the office, while balancing individual flexibility. Why AstraZeneca? We are committed to making a difference and have built our business around our passion for science. We’re fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. Our curiosity and courage drive us to do things that haven’t been done before—empowered to step up, make bold decisions, and learn from successes and failures. Ready to make a significant impact? Apply now and join us on this exciting journey! Date Posted 26-Jan-2026 Closing Date 07-Feb-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

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