Senior/Principal AI Scientist for Large Molecule - AIDD job opportunity at Roche.

Home Jobs In China Tag: Job Senior/Principal AI Scientist for Large Molecule - AIDD position at Roche


DateMore Than 30 Days Ago bot
Roche Senior/Principal AI Scientist for Large Molecule - AIDD
Experience: 3-years
Pattern: full-time
Country:
apply Apply Now
Salary:
Status:

Job

Copy Link Report
degreeOND
loacation Shanghai, China
loacation Shanghai....China

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. The Position Primary Purpose of Job The China Innovation Center of Roche (CICoR) is seeking a highly skilled Artificial Intelligence (AI) scientist to join the AI, Data and Digital (AIDD) team. This pivotal role focuses on applying cutting-edge AI/Machine Learning (ML) methodologies to large molecule drug discovery, especially antibodies, to revolutionize their design, discovery, optimization, and understanding. The successful candidate will work in an exciting and multidisciplinary environment alongside AI researchers, ML engineers, and computational scientists, committing to driving innovation through cutting-edge AI methods with real-world impact in the drug discovery field. Responsibilities Lead the AI strategy to establish and develop capabilities for large molecule drug discovery to enhance drug portfolio success and R&D productivity in CICoR. Identify, develop and implement advanced AI/ML models and solutions for antigen-antibody interactions, antibody design, engineering, and optimization. Collaborate extensively with Biologics Discovery & Development (BDD) team including antibody engineers and experimental scientists to develop best- or first-in-class antibody therapeutics. Explore and stay current in cutting edge AI models (e.g., multimodal, large language model, diffusion) for antibody de novo generation, affinity maturation, developability optimization, immunogenicity, dual specific antibody and new emerging portfolio needs. Communicate with data scientists, AI researchers and informatics experts within AIDD and across Roche organization (e.g., pRED, Genentech, Roche Informatics) to exchange learnings and collaborate on projects. (For Principal) : Lead significant AI/ML projects/initiatives across CICoR or global Roche sites, providing technical leadership and mentorship. Requirements Ph.D. in Machine Learning, Computer Science, Computational Biology, Biological Science, Structural biology, Bioinformatics, Biophysics, Chemistry, or a closely related quantitative discipline. Senior Scientist: Minimum 3+ years of industry experience (post-Ph.D) in applying AI/ML to biologics discovery (pharmaceutical, biotech, or relevant AI startup preferred). Principal Scientist: Minimum 7+ years of industry experience (post-Ph.D), demonstrating significant leadership in computational and AI/ML biologics discovery, a strong publication record, and proven mentorship ability. Profound expertise in developing and applying state-of-the-art deep learning models (e.g., GNNs, Transformers, GANs, VAEs, Diffusion and LLMs). Strong programming skills in Python and proficiency in deep learning frameworks (PyTorch/TensorFlow). Deep understanding and hands-on experience on construction or modification of AI/ML and computational applications in large molecule drug discovery, for example: Protein structure prediction (e.g., AlphaFold3, ABodyBuilder2) for antigen-antibody complexes. Antigen-antibody binding affinity prediction and optimization (e.g. AlphaBind). Protein sequence design and inverse folding (e.g., ProteinMPNN or AbMPNN for antibody CDRs, including ensemble methods). Computational protein modeling, design, and analysis (e.g., Rosetta, MOE) for antibody engineering, ligand docking, macromolecular interactions. De novo antibody design by diffusion or foundation models (e.g., RFdiffusion, Chai-1/2) to generate a novel and  high-affinity antibody. Developability and multi-parameter optimization for antibodies with integrating high-thoughtput and automated wet-lab platforms (lab-in-the-loop). Strong passion for applying AI to drug R&D, continuous learning in large molecules, and excellent problem-solving skills. Ability to critically assess, adapt, and innovate upon existing and cutting-edge AI/ML tools to solve novel biologics problems. Experience in AIOps/MLOps, container orchestration (Kubernetes), cloud-native development, or high-performance computing (HPC) environments is a plus. Strong communication skills in both English and Mandarin. Self-motivated, collaborative and agile mindset, thriving in a fast-paced, innovative environment. (For Principal) : Proven leadership and track records in successfully driving impactful AI solutions and project management. Who we are A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact. Let’s build a healthier future, together. Roche is an Equal Opportunity Employer.

Other Ai Matches

Healthcare Policy and Value Partner Applicants are expected to have a solid experience in handling Job related tasks
Sales Specialist Core Lab Solutions for Brussels and Wallonia Applicants are expected to have a solid experience in handling Job related tasks
Ausbildung 2026: Bachelor of Engineering, Wirtschaftsingenieurwesen, Standort Ludwigsburg Applicants are expected to have a solid experience in handling Wirtschaftsingenieurwesen, Standort Ludwigsburg related tasks
治疗领域经理 - 乳腺癌治疗领域 Applicants are expected to have a solid experience in handling Job related tasks
Manufacturing Engineer/ Sr. Engineer-Mechanical Applicants are expected to have a solid experience in handling Job related tasks
Lehrstelle als Laborant:in EFZ Fachrichtung Chemie (ab August 2025) Applicants are expected to have a solid experience in handling Job related tasks
Matrix Lead in Analytics Applicants are expected to have a solid experience in handling Job related tasks
Patient Journey Partner Applicants are expected to have a solid experience in handling Job related tasks
DMR（営業職_東京） Applicants are expected to have a solid experience in handling Job related tasks
Sales Representative Applicants are expected to have a solid experience in handling Job related tasks
Scientist - Organoid Single-cell Genomics Applicants are expected to have a solid experience in handling Job related tasks
Commercial Analytics Business Analyst (fixed-term) Applicants are expected to have a solid experience in handling Job related tasks
Senior Statistician Applicants are expected to have a solid experience in handling Job related tasks
(Sr)Electricity Engineer Applicants are expected to have a solid experience in handling Job related tasks
Legal Intern Applicants are expected to have a solid experience in handling Job related tasks
Regional Account Specialist Applicants are expected to have a solid experience in handling Job related tasks
IT Security Engineer Applicants are expected to have a solid experience in handling Job related tasks
Patient Journey Partner Applicants are expected to have a solid experience in handling Job related tasks
Marketing Intern Applicants are expected to have a solid experience in handling Job related tasks
Chef de Partie – Schöpfli im Park (w/m/d), 100% - befristet Applicants are expected to have a solid experience in handling 100% - befristet related tasks
Content Editor Applicants are expected to have a solid experience in handling Job related tasks
实习医药信息顾问 Applicants are expected to have a solid experience in handling Job related tasks
GMP Service Manager Applicants are expected to have a solid experience in handling Job related tasks