Principal Associate job opportunity at Roche.

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DateMore Than 30 Days Ago bot
Roche Principal Associate
Experience: 5-years
Pattern: full-time
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degreeAssociate
loacation Shanghai, China
loacation Shanghai....China

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. The Position At Roche, over 90,000 colleagues are working together and doing what patients need next.  Our ambition is to deliver novel therapeutics, diagnostic solutions and insights to patients with game changing clinical benefits. Antibody Engineering at Roche Innovation Center Shanghai is seeking a talented and experienced Senior Associate or Principal Associate for antibody discovery work, including antibody hits identification by phage or yeast display systems, library build, and the characterization and optimization of lead antibody compounds. The final position offered depends the experience level of the candidate.  Actual responsibilities will vary according to specific roles.  The position requires the candidate to execute phage/yeast display screening, development and screening of in vitro binding assays and functional cell-based assays, to contribute to optimization of therapeutic antibody leads. The successful candidate will work with dynamic and highly motivated teams to drive the development of antibody therapeutics for unmet medical needs. The candidate will collaborate effectively with colleagues in Antibody Engineering, Lead Discovery, Protein Sciences, Structural Biology, Immunology, Oncology, and Pharmaceutical Sciences. RESPONSIBILITIES Execute yeast and/or phage based display system  for antibody discovery.  Experience for library-build and single B cell workflow will be greatly valued but not a must. Develop and perform in vitro binding assays for the screening and characterization of therapeutic antibody hits including immuno-binding assays including ELISAs, FACS, affinity measurement assays, antibody epitope mapping assays, and functional biochemical and cell-based assays in various disease areas Execute profiling/screening to deliver data to guide lead optimization Monitor outsourcing activities at CROs to ensure timely delivery of qualified data to steer portfolios Independently analyzes, interprets and presents results within and outside Antibody Engineering Coordinates cross-functional efforts to meet near-term or long-term project goals CANDIDATE PROFILE Qualification and experience The candidate qualifications include an MS degree in biochemistry, cell biology or molecular biology and at least 5 years of recent relevant antibody discovery experience preferably in a biopharmaceutical industry setting.   Competencies The ideal candidate will have demonstrated competence in the following areas: Deep hands-on experience in molecular biology, biochemical and cell-based assay development, and familiar with relevant instruments Hands-on experience in yeast/phage display technologies and related workflows in the context of antibody discovery Familiar with high-throughput & high-content screening set up and relevant instruments. Experience in Immunology, Oncology and other disease areas is highly desirable Experience with single B cell system is highly desirable Proven ability in independent and reliable execution of antibody discovery work with a persistent record of productivity, agile problem solving capability and aptitude in quickly learning new technologies/skills. Excellent communication and collaboration skills with a deep commitment to working in a fast paced team setting. Who we are A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact. Let’s build a healthier future, together. Roche is an Equal Opportunity Employer.

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